We hypothesized that microvascular invasion (MVI) and post-resection prognosis in patients with solitary hepatocellular carcinoma (HCC) could be predicted using blood tumor markers and tumor volume (TV). We intended to identify a simple surrogate marker of HCC via a combination of clinical variables.This retrospective study used the strictly selected development cohort (n = 1176) and validation cohort (n = 551) containing patients who underwent curative resection of solitary HCC.In the development cohort study, the median values were 13.7 mL for TV, 24.2 ng/mL for α-fetoprotein (AFP), and 75 mAU/mL for des-γ-carboxy prothrombin (DCP); there was no correlation among these three factors (r 2 ≤ 0.237, p < 0.001). The 1-, 3-, and 5-year rates were 22.4, 41.7, and 46.8 

作者：Shin, Hwang；Gi-Won, Song；Young-Joo, Lee；Ki-Hun, Kim；Chul-Soo, Ahn；Deok-Bog, Moon；Tae-Yong, Ha；Dong-Hwan, Jung；Gil-Chun, Park；Sung-Gyu, Lee

来源：Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2016 年 20卷 11期