To compare the efficacy and adverse effects of high and standard dose atorvastatin in ST elevation myocardial infarction (STEMI) patients.A prospective, single-centre, randomised, double blind study.A tertiary care centre in Kerala, India, from January to June 2009.121 consecutive acute STEMI patients eligible for thrombolytic therapy.Pharmacological thrombolysis and atorvastatin therapy.Primary end points were mean change in low density lipoprotein and total cholesterol, serum glutamic pyruvic transaminase (SGPT), creatine phosphokinase (CPK) at 3 months of high dose (80 mg) and standard dose (20 mg) of atorvastatin.There was no significant difference in the mean cholesterol levels at 3 months of therapy (mean reduction in total cholesterol and low density lipoprotein cholesterol were 48 mg

作者：Gailin B, Sebastian；T M, Anoop；Joby K, Thomas；Raju, George

来源：Heart Asia 2011 年 3卷 1期