The aim of this study was to evaluate the course of SSc-related pulmonary abnormalities following high-dose chemotherapy with autologous stem cell transplantation (SCT) by quantitative chest CT analysis and compare the results with those of pulmonary function tests and the response of cutaneous involvement.Chest CT quantification was performed before, directly after [0.49 years (sd 0.20)] and at a mean of 2.2 years (sd 2.1) following autologous SCT in 26 consecutive patients with SSc between March 2001 and March 2015. Quantitative CT used fully automated software to calculate inspiratory total lung volume, mean lung density, high attenuation value and their pulmonary distribution (core vs peel). All patients underwent pulmonary function tests. We additionally analysed parallels in the response of associated skin changes by using the modified Rodnan skin score (mRSS).The forced vital capacity (FVC) course at 6 months was used to classify patients into responders [n = 20 (76.9

作者：Christopher, Kloth；Wolfgang, Maximilian Thaiss；Heike, Preibsch；Klemens, Mark；Ina, K?tter；Jürgen, Hetzel；Konstantin, Nikolaou；J?rg, Henes；Marius, Horger

来源：Rheumatology (Oxford, England) 2016 年 55卷 10期