Autopsy studies suggest that cerebral amyloid angiopathy (CAA) is associated with cognitive impairment and risk for dementia. We analyzed neuropsychological test data from a prospective cohort study of patients with CAA to identify the prevalence of cognitive impairment and its associations with brain magnetic resonance imaging features and the apolipoprotein E genotype.Data were analyzed from 34 CAA, 16 Alzheimer's disease, 69 mild cognitive impairment, and 27 ischemic stroke participants. Neuropsychological test results were expressed as z scores in relation to normative data provided by the test manuals and then grouped into domains of memory, executive function, and processing speed.Mean test scores in CAA participants were significantly lower than norms for memory (-0.44±1.03; P=0.02), executive function (-1.14±1.07; P<0.001), and processing speed (-1.06±1.12; P<0.001). Twenty-seven CAA participants (79

作者：Nevicia F, Case；Anna, Charlton；Angela, Zwiers；Saima, Batool；Cheryl R, McCreary；David B, Hogan；Zahinoor, Ismail；Charlotte, Zerna；Shelagh B, Coutts；Richard, Frayne；Brad, Goodyear；Angela, Haffenden；Eric E, Smith

来源：Stroke 2016 年 47卷 8期