Design and protocol for the Focusing on Clozapine Unresponsive Symptoms (FOCUS) trial: a randomised controlled trial.-临床诊疗知识库

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For around a third of people with a diagnosis of schizophrenia, the condition proves to respond poorly to treatment with many typical and atypical antipsychotics. This is commonly referred to as treatment-resistant schizophrenia. Clozapine is the only antipsychotic with convincing efficacy for people whose symptoms are considered treatment-resistant to antipsychotic medication. However, 30-40

作者：Melissa, Pyle；John, Norrie；Matthias, Schwannauer；David, Kingdon；Andrew, Gumley；Douglas, Turkington；Rory, Byrne；Suzy, Syrett；Graeme, MacLennan；Robert, Dudley；Hamish J, McLeod；Helen, Griffiths；Samantha, Bowe；Thomas R E, Barnes；Paul, French；Paul, Hutton；Linda, Davies；Anthony P, Morrison

来源：BMC psychiatry 2016 年 16卷

循证病因循证诊断循证治疗循证预后随机对照研究

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