In order to realize accurate localization and precise evaluation of vulnerability of atherosclerotic plaques via dual-modal imaging, gold nanoparticles (GNPs) were firstly caped with a thin amino-PEGs cover and then conjugated with the targeting molecular Annexin V and radionuclide Tc-99m simultaneously to form SPECT/CT imaging probe targeting apoptotic macrophages. The as-synthesized (99m)Tc-GNPs-Annexin V was with uniform size (30.2 ± 2.9 nm) and high labeling rate (98.9 ± 0.5
作者：Xiao, Li；Cong, Wang；Hui, Tan；Leilei, Cheng；Guobing, Liu；Yi, Yang；Yanzhao, Zhao；Yiqiu, Zhang；Yanli, Li；Chunfu, Zhang；Yan, Xiu；Dengfeng, Cheng；Hongcheng, Shi
来源：Biomaterials 2016 年 108卷
