Effects on non-motor symptoms, mainly cognitive and psychiatric side effects, could influence the decision for either globus pallidus pars interna (GPi) or subthalamic nucleus (STN) deep brain stimulation (DBS) for patients with Parkinson's disease (PD).1) To compare cognitive and psychiatric outcomes 3 years after GPi DBS versus STN DBS, and 2) to report on occurrence of suicidal ideation, psychiatric diagnoses, social functioning, and marital satisfaction 3 years after DBS.Patients were randomized to receive GPi DBS (n = 65) or STN DBS (n = 63). Standardized assessments were performed at baseline, 1 year, and 3 years. We used linear mixed model analyses to investigate between-group differences on the Mattis Dementia Rating Scale (MDRS), neuropsychological tests, and psychiatric questionnaires 3 years after DBS.Eighty-seven patients (68

作者：Judith A, Boel；Vincent J J, Odekerken；Ben A, Schmand；Gert J, Geurtsen；Danielle C, Cath；Martijn, Figee；Pepijn, van den Munckhof；Rob J, de Haan；P Richard, Schuurman；Rob M A, de Bie

来源：Parkinsonism & related disorders 2016 年 33卷