The disproportion between the large organ demand and the low number of transplantations performed represents a serious public health problem worldwide. Reducing the loss of transplantable organs from deceased potential donors as a function of cardiac arrest (CA) may contribute to an increase in organ donations. Our purpose was to test the hypothesis that a goal-directed protocol to guide the management of deceased donors may reduce the losses of potential brain-dead donors (PBDDs) due to CA.The quality improvement project included 27 hospitals that reported deceased donors prospectively to the Transplant Center of the State of Santa Catarina, Brazil. All deceased donors reported prospectively between May 2012 and April 2014 were analyzed. Hospitals were encouraged to use the VIP approach checklist during the management of PBDDs. The checklist was composed of the following goals: protocol duration 12-24 hours, temperature > 35 °C, mean arterial pressure ≥ 65 mmHg, diuresis 1-4 ml/kg/h, corticosteroids, vasopressin, tidal volume 6-8 ml/kg, positive end-expiratory pressure 8-10 cmH2O, sodium < 150 mEq/L, and glycemia < 180 mg/dl. A logistic regression model was used to identify predictors of CA.There were 726 PBDD notifications, of which 324 (44.6) were actual donors, 141 (19.4 

作者：Glauco A, Westphal；Elisabeth, Coll；Rafael L, de Souza；Silvana, Wagner；Artur, Montemezzo；Fernanda Carolina, Cani de Souza；Gabriel, Torres；Stefan, Halla；Tiago C, Carnin；Míriam C, Machado；Eduardo, Berbigier；Fernando, Busetto；Ivonei, Bittencourt；Karine, Gerent；Bruno S, de Souza；Manoel, Tassinari；Joel, de Andrade

来源：Critical care (London, England) 2016 年 20卷 1期