Triple Negative Breast Cancer (TNBC), a clinically aggressive subtype of breast cancer, disproportionately affects African American (AA) women when compared to non-Hispanic Whites (NHW). MiRNAs(miRNAs) play a critical role in these tumors, through the regulation of cancer driver genes. In this study, our goal was to characterize and compare the patterns of miRNA expression in TNBC of AA (n = 27) and NHW women (n = 30). A total of 256 miRNAs were differentially expressed between these groups, and distinct from the ones observed in their respective non-TNBC subtypes. Fifty-five of these miRNAs were mapped in cytobands carrying copy number alterations (CNAs); 26 of them presented expression levels concordant with the observed CNAs. Receiving operating characteristic (ROC) analysis showed a good power (AUC ≥ 0.80; 95

作者：Bruna, Sugita；Mandeep, Gill；Akanskha, Mahajan；Anju, Duttargi；Saurabh, Kirolikar；Rodrigo, Almeida；Kenny, Regis；Olusayo L, Oluwasanmi；Fabio, Marchi；Catalin, Marian；Kepher, Makambi；Bhaskar, Kallakury；Laura, Sheahan；Iglenir J, Cavalli；Enilze M, Ribeiro；Subha, Madhavan；Simina, Boca；Yuriy, Gusev；Luciane R, Cavalli

来源：Oncotarget 2016 年