Recently a low-volume polyethylene glycol containing ascorbic acid (PEG-Asc) formulation has proven as safe and effective as traditional 4L PEG solutions for colonoscopy preparation. However, currently available aqueous purgative formulations are poorly tolerated. The aim of this study was to compare a split-dose 2L PEG-Asc and a 1L PEG-Asc with bisacodyl (10 mg) formulation to determine the quality of bowel cleansing and patient tolerability.A single-center, randomized, observer-blinded study was performed between May 2015 and September 2015. Two hundred outpatients referred for colonoscopy were prospectively enrolled and assigned to either the split-dose 2L PEG-Asc or the 1L PEG-Asc with bisacodyl 10-mg groups. The Boston Bowel Preparation Scale (BBPS) and Aronchick Preparation Scale (APS) were used to evaluate bowel cleansing. The tolerability of the regimens and satisfaction of patients was determined based on a questionnaire.Two hundred patients received either 2L PEG-Asc or 1L PEG-Asc with bisacodyl. Regarding colon cleansing outcome (BPPS and APS), the 1L PEG-Asc with bisacodyl group showed similar, but non-inferior results compared with the 2L PEG-Asc group on both BBPS (6.92 ± 1.63 vs 6.57 ± 1.37, P = .103) and APS (96

作者：Seung Hun, Kang；Yoon Tae, Jeen；Jae Hyung, Lee；In Kyung, Yoo；Jae Min, Lee；Seung Han, Kim；Hyuk Soon, Choi；Eun Sun, Kim；Bora, Keum；Hong Sik, Lee；Hoon Jai, Chun；Chang Duck, Kim

来源：Gastrointestinal endoscopy 2016 年