To evaluate the effectiveness and safety of nucleoside antiviral drugs for the treatment of recurrent herpes labialis.Randomized controlled trials that examined the effectiveness and/or safety of nucleoside antiviral drugs for recurrent herpes labialis were identified via a literature search. The parameters used to measure efficacy were time-to-healing of classic and all lesions, time-to-resolution of pain, and percentage of aborted lesions. Safety was assessed by evaluating the adverse events reported during treatment. Subgroup analyses based on the mode of application (topical/systemic) and type of nucleoside antiviral drugs were performed, as were sensitivity analyses of studies with a low risk of bias.Our analysis included 16 publications reporting 25 randomized controlled trials (8453 patients). Nucleoside antiviral drugs decreased the time-to-healing of all lesions (mean difference: -0.74 days; 95

作者：Fangman, Chen；Hao, Xu；Jinli, Liu；Yuan, Cui；Xiaobo, Luo；Yu, Zhou；Qianming, Chen；Lu, Jiang

来源：Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2016 年