To clarify the survival and prognostic factors in patients with Child-Turcotte-Pugh class C (CTP-C) cirrhosis.From all candidates for deceased donor liver transplantation in Japan between 2007 and 2015, 1014 adult patients with CTP-C cirrhosis were retrospectively enrolled in this study. The hazard ratio (HR) of factors associated with mortality was estimated by the Cox proportional hazard model. The survival probabilities were evaluated by Kaplan-Meier analysis and the log-rank test.Median survival time of the entire cohort was 475 days. Univariate analysis identified age, CTP, Model for End-Stage Liver Disease (MELD) score, and primary biliary cholangitis (PBC) as significant variables associated with mortality and hepatitis B virus (HBV) infection as a close-to-significant variable. Multivariate analysis revealed that age-adjusted mortality risk increased by 59
作者:Takuya, Genda;Takafumi, Ichida;Shotaro, Sakisaka;Eiji, Tanaka;Satoshi, Mochida;Yoshiyuki, Ueno;Ayano, Inui;Hiroto, Egawa;Koji, Umeshita;Hiroyuki, Furukawa;Seiji, Kawasaki;Yukihiro, Inomata
来源:Hepatology research : the official journal of the Japan Society of Hepatology 2016 年