To meta-analytically examine the trends and correlates of antipsychotic use in youth with mood disorders.Systematic literature search without language restriction in PubMed/MEDLINE/PsycINFO from database inception through March 2015 using the following search terms: (antipsychotic* OR neuroleptic* OR "dopamine blocker*" OR antidopaminergic) AND (child* OR adolescen* OR pediatric OR youth) AND (prescription* OR prescrib* OR use OR utilization OR database OR pharmacoepidemiolog* OR frequency OR rate OR rates). Random effects meta-analysis and meta-regression analyses were conducted.Included were studies reporting on the frequency of (1) mood disorders in antipsychotic-treated youth (≤ 19 years) and (2) antipsychotic use in youth with mood disorders.Two independent investigators abstracted data on study, patient, and treatment characteristics.Forty-one studies were meta-analyzed (N = 518,919, mean ± SD age = 12.8 ± 1.8 years, males = 65.7

作者：Chiara, Cervesi；Su Young, Park；Britta, Galling；Silvia, Molteni；Gabriele, Masi；Tobias, Gerhard；Mark, Olfson；Christoph U, Correll

来源：The Journal of clinical psychiatry 2017 年 78卷 3期