It is demonstrated that carboxylic acid-functionalized titanium dioxide (TiO2) NPs produce significantly higher levels of reactive oxygen species (ROS) after visible light irradiation (400-800nm, 1600mW/cm2) in comparison to nonfunctionalized TiO2 NPs. The level of ROS produced under these irradiation conditions was not capable of generating oxidatively induced DNA damage in a cell-free system for TiO2 concentrations of 0.5mg/L or 5mg/L. In addition, specific incorporation of the acrylic acid-functionalized TiO2 NPs into dental composites allowed us to utilize the generated ROS to enhance photopolymerization (curing and degree of vinyl conversion (DC)) of resin adhesives and create mechanically superior and biocompatible materials for dental applications. Incorporation of the TiO2 NPs into selected dental composites increased the mean DC values by ≈7
作者:Jirun, Sun;Elijah J, Petersen;Stephanie S, Watson;Christopher M, Sims;Alexander, Kassman;Stanislav, Frukhtbeyn;Drago, Skrtic;Meryem T, Ok;Debbie S, Jacobs;Vytas, Reipa;Qiang, Ye;Bryant C, Nelson
来源:Acta biomaterialia 2017 年 53卷