The effect of short-term oral treatment with omeprazole or pantoprazole on the function of polymorphonuclear neutrophils.-临床诊疗知识库

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Recent studies report an increased risk of enteric infections in patients treated with proton pump inhibitors (PPIs). Polymorphonuclear neutrophils (PMNs) play a key role in host response to bacterial infection. We evaluated the effect of omeprazole and pantoprazole treatment on the PMN function. Fifteen patients were treated with omeprazole 20 mg daily and 15 patients with pantoprazole 40 mg daily for 7 days. Treatment with omeprazole or pantoprazole had no effect on spontaneous nitroblue tetrazolium (NBT) test results. Significant increase in the percentage of phagocytes in the omeprazole group in stimulated NBT test (by 69

作者：Maja, Kostrzewska；Marzena, Garley；Wioletta, Ratajczak-Wrona；Ewa, Jab?ońska；Jacek, Jamio?kowski；Andrzej, Dabrowski

来源：Canadian journal of physiology and pharmacology 2017 年 95卷 6期

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The effect of short-term oral treatment with omeprazole or pantoprazole on the function of polymorphonuclear neutrophils.

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作者：

Maja, Kostrzewska；Marzena, Garley；Wioletta, Ratajczak-Wrona；Ewa, Jab?ońska；Jacek, Jamio?kowski；Andrzej, Dabrowski

来源：

Canadian journal of physiology and pharmacology 2017 年 95卷 6期

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cyclic guanosine monophosphate guanosine monophosphate cyclique inhibiteurs de la pompe à proton neutrophiles polynucléaires nitric oxide nitric oxide synthase nitroblue tetrazolium test omeprazole oméprazole oxyde nitrique oxyde nitrique synthase p38 mitogen-activated protein kinase pantoprazole polymorphonuclear neutrophils proton pump inhibitors protéine kinase activée par l’agent mitogène p38 test au nitrobleu de tétrazolium

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