Critically ill patients, among whom acute kidney injury is common, are often considered particularly vulnerable to iodinated contrast medium nephrotoxicity. However, the attributable incidence remains uncertain given the paucity of observational studies including a control group. This study assessed acute kidney injury incidence attributable to iodinated contrast media in critically ill patients based on new data accounting for sample and effect size and including a control group.Systematic review of studies measuring incidence of acute kidney injury in critically ill patients following contrast medium exposure compared to matched unexposed patients. Patient-level meta-analysis implementing a Bayesian nested mixed effects multiple logistic regression model.Ten studies were identified; only four took into account the baseline acute kidney injury risk, three by patient matching (560 patients). Objective meta-analysis of these three studies (vague and impartial a priori hypothesis concerning attributable acute kidney injury risk) did not find that iodinated contrast media increased the incidence of acute kidney injury (odds ratio 0.95, 95

作者：Stephan, Ehrmann；Andrew, Quartin；Brian P, Hobbs；Vincent, Robert-Edan；Cynthia, Cely；Cynthia, Bell；Genevieve, Lyons；Tai, Pham；Roland, Schein；Yimin, Geng；Karim, Lakhal；Chaan S, Ng

来源：Intensive care medicine 2017 年 43卷 6期