To evaluate the effectiveness of dienogest in controlling pain caused by deep infiltrating endometriosis (DIE), its influence on the quality of live (QoL) of women affected by the disease, and the effect of the drug on the volume of endometriotic lesions.A prospective cohort study including 30 women with a sonographic diagnosis of DIE (intestinal and posterior fornix) treated with dienogest 2mg per day for 12 months. We evaluated the pain symptoms and the volume of the intestinal and posterior fornix lesions before and after 12 months of use of dienogest. To perform the statistical analysis, we used the Wilcoxon signed-rank test, and the relationship between the data was tested using the Spearman correlation coefficient.Women were on average 36.13±6.24years old. Pain symptoms most commonly reported were dyspareunia (83.3

作者：Joao Paulo, Leonardo-Pinto；Cristina Laguna, Benetti-Pinto；Kleber, Cursino；Daniela Angerame, Yela

来源：European journal of obstetrics, gynecology, and reproductive biology 2017 年 211卷