Chlorthalidone is a very effective antihypertensive drug, but it has not been studied prospectively in kidney transplant recipients with hypertension. Recent data indicate that calcineurin inhibitors activate the thiazide-sensitive sodium chloride cotransporter, providing further rationale to test thiazides in this population.Randomized noninferiority crossover trial (noninferiority margin, -2.8mmHg).Hypertensive kidney transplant recipients using tacrolimus (median duration, 2.4 years after transplantation; mean estimated glomerular filtration rate, 63±27 [SD] mL/min/1.73m2; mean systolic blood pressure [SBP], 151±12mmHg).Amlodipine (5-10mg) and chlorthalidone (12.5-25mg) for 8 weeks (separated by 2-week washout).Average daytime (9 am to 9 pm) ambulatory SBP.Blood pressure and laboratory parameters.88 patients underwent ambulatory blood pressure monitoring, of whom 49 (56

作者：Arthur D, Moes；Dennis A, Hesselink；Anton H, van den Meiracker；Robert, Zietse；Ewout J, Hoorn

来源：American journal of kidney diseases : the official journal of the National Kidney Foundation 2017 年 69卷 6期