OBJECT In clinical routines, neuroprotective strategies in neurosurgical interventions are still missing. A pilot study (n = 30) and an analogously performed Phase III trial (n = 112) pointed to a beneficial effect of prophylactic nimodipine and hydroxyethyl starch (HES) in vestibular schwannoma (VS) surgery. Considering the small sample size, the data from both studies were pooled. METHODS The patients in both investigator-initiated studies were assigned to 2 groups. The treatment group (n = 70) received parenteral nimodipine (1-2 mg/hour) and HES (hematocrit 30

作者：Christian, Scheller；Andreas, Wienke；Marcos, Tatagiba；Alireza, Gharabaghi；Kristofer F, Ramina；Oliver, Ganslandt；Barbara, Bischoff；Johannes, Zenk；Tobias, Engelhorn；Cordula, Matthies；Thomas, Westermaier；Gregor, Antoniadis；Maria Teresa, Pedro；Veit, Rohde；Kajetan, von Eckardstein；Thomas, Kretschmer；Malte, Kornhuber；J?rg, Steighardt；Michael, Richter；Fred G, Barker；Christian, Strauss

来源：Journal of neurosurgery 2017 年