Clinical Long-Term Response to Cardiac Resynchronization Therapy Is Independent of Persisting Echocardiographic Markers of Dyssynchrony.-临床诊疗知识库

Clinical Long-Term Response to Cardiac Resynchronization Therapy Is Independent of Persisting Echocardiographic Markers of Dyssynchrony.

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作者：

Barbara, Naegeli；Hans-Peter, Brunner-La Rocca；Christine, Attenhofer Jost；Anja, Fah-Gunz；Dominik, Maurer；Osmund, Bertel；Christoph, Scharf

来源：

Cardiology research 2014 年 5卷 6期

标签：

Cardiac resynchronization therapy Doppler Dyssynchrony Echocardiography Heart failure Outcome

The aim of the study was to prove the concept that correction of established parameters of dyssynchrony is a requirement for favorable long-term outcome in patients with cardiac resynchronization therapy (CRT), whereas patients with persisting dyssynchrony should have a less favorable response.After CRT implantation and optimization of dyssynchrony parameters, we evaluated whether correction or persistence of dyssynchrony predicted long-term outcome. Primary endpoint was a combination of cardiac mortality/heart transplantation and hospitalization due to worsening heart failure, and secondary endpoint was NYHA class.One hundred twenty-eight consecutive patients (mean age 68 ± 10 years) undergoing CRT with a mean left ventricular ejection fraction of 27±9

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