Contradictory findings have been reported regarding the safety and efficacy of digitalis in patients recovering from acute myocardial infarction (MI). We studied the association of digitalis use with long-term and short-term prognosis in patients presenting with an acute MI complicated with heart failure (HF), left ventricular dysfunction, or both.Using the High-Risk MI Database Initiative combining data from 4 major clinical trials, totaling 27,673 patients, we investigated the association between digitalis use at baseline (3093 patients with digitalis and 24,580 without) with the rate of all-cause death, sudden cardiac death, cardiovascular death, HF hospitalization and the combination of the latter two, over a mean follow-up time of 2.7 years. Patients with and without atrial fibrillation (AF) were studied separately. After a propensity score-based analysis, among patients without AF, those receiving digitalis experienced a higher rate of all-cause [hazard ratio (HR) 1.54, 95

作者：Stefano, Coiro；Nicolas, Girerd；Patrick, Rossignol；Johann, Bauersachs；Bertram, Pitt；Renaud, Fay；Giuseppe, Ambrosio；Scott D, Solomon；Kenneth, Dickstein；Faiez, Zannad

来源：Clinical research in cardiology : official journal of the German Cardiac Society 2017 年