Toward Successful Cyclodextrin Based Solubility-Enabling Formulations for Oral Delivery of Lipophilic Drugs: Solubility-Permeability Trade-Off, Biorelevant Dissolution, and the Unstirred Water Layer.-临床诊疗知识库

首页 > Molecular pharmaceutics > Toward Successful Cyclodextrin Based Solubility-Enabling Formulations for Oral Deliver...

收藏 | 浏览36

The purpose of this work was to investigate key factors dictating the success/failure of cyclodextrin-based solubility-enabling formulations for oral delivery of low-solubility drugs. We have studied the solubility, the permeability, and the solubility-permeability interplay, of the highly lipophilic drug danazol, formulated with different levels (8.5, 10, 20, and 30

作者：Noa, Fine-Shamir；Avital, Beig；Moran, Zur；David, Lindley；Jonathan M, Miller；Arik, Dahan

来源：Molecular pharmaceutics 2017 年 14卷 6期

循证预后系统评价与Meta分析

相似文献

知识库介绍

临床诊疗知识库该平台旨在解决临床医护人员在学习、工作中对医学信息的需求，方便快速、便捷的获取实用的医学信息，辅助临床决策参考。该库包含疾病、药品、检查、指南规范、病例文献及循证文献等多种丰富权威的临床资源。

详细介绍

热门关注

免责声明：本知识库提供的有关内容等信息仅供学习参考，不代替医生的诊断和医嘱。

Toward Successful Cyclodextrin Based Solubility-Enabling Formulations for Oral Delivery of Lipophilic Drugs: Solubility-Permeability Trade-Off, Biorelevant Dissolution, and the Unstirred Water Layer.

| 浏览：36

作者：

Noa, Fine-Shamir；Avital, Beig；Moran, Zur；David, Lindley；Jonathan M, Miller；Arik, Dahan

来源：

Molecular pharmaceutics 2017 年 14卷 6期

标签：

cyclodextrins drug absorption intestinal permeability low solubility oral drug delivery solubility-enabling formulations solubility?permeability interplay

知识库介绍

详细介绍

临床诊疗知识库现支持机构用户及个人包时用户开通服务。如需开通机构账号，请机构管理员联系我们，联系电话：010-58882667；个人包时开通请直接点击“个人包时订购”，开通后即可使用。

相似文献