Hypovitaminosis D has been associated with several chronic conditions; yet, its association with cognitive decline and the risk of dementia and Alzheimer's disease (AD) has been inconsistent.The study population consisted of 916 participants from the Three-City Bordeaux cohort aged 65+, nondemented at baseline, with assessment of vitamin D status and who were followed for up to 12 years.In multivariate analysis, compared with individuals with 25(OH)D sufficiency (n = 151), participants with 25(OH)D deficiency (n = 218) exhibited a faster cognitive decline. A total of 177 dementia cases (124 AD) occurred: 25(OH)D deficiency was associated with a nearly three-fold increased risk of AD (hazard ratio = 2.85, 95

作者：Catherine, Feart；Catherine, Helmer；Bénédicte, Merle；Fran?ois R, Herrmann；Cédric, Annweiler；Jean-Fran?ois, Dartigues；Cécile, Delcourt；Cécilia, Samieri

来源：Alzheimer's & dementia : the journal of the Alzheimer's Association 2017 年