Depressive symptoms are prevalent in patients with mild cognitive impairment (MCI) and are considered to be a risk factor for progression to dementia.The purpose of this study was to evaluate whether depressive symptoms in MCI promote disease progression in a manner related to amyloid status, and to determine the relationship between depressive symptoms and longitudinal cerebral structural changes.Baseline data for 336 patients with MCI (75 with depression and 261 without) from the Alzheimer's Disease Neuroimaging Initiative study were analyzed. All participants underwent comprehensive cognitive testing, volumetric magnetic resonance imaging (MRI), and [18F]AV45 positron emission tomography amyloid imaging. Depressive symptoms were measured using the Neuropsychiatric Inventory Questionnaire. A voxel-based morphometric analysis using volumetric brain MRI data was used to compare longitudinal structural changes related to depressive symptoms.The conversion rate to dementia was different between patients with and without depression in amyloid-positive MCI (40.8

作者：Byungseung, Moon；Seongheon, Kim；Young Ho, Park；Jae-Sung, Lim；Young Chul, Youn；SangYun, Kim；Jae-Won, Jang

来源：Journal of Alzheimer's disease : JAD 2017 年 58卷 4期