A review of vilazodone exposures with focus on serotonin syndrome effects.-临床诊疗知识库

A review of vilazodone exposures with focus on serotonin syndrome effects.

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作者：

C William, Heise；Hannah, Malashock；Daniel E, Brooks

来源：

Clinical toxicology (Philadelphia, Pa.) 2017 年

标签：

Vilazodone antidepressants serotonergic serotonin syndrome

Vilazodone is an antidepressant with selective serotonin reuptake inhibition and partial 5HT1A agonism. Serotonin syndrome is believed to be due to excessive stimulation of 5-HT2A and 5-HT1A receptors, resulting in the clinical triad of altered mentation, autonomic instability and neuromuscular abnormalities. The goal of this study is to define serotonergic effects after vilazodone exposure.A retrospective review of two databases: the American Association of Poison Controls Centers' National Poison Data System (NPDS) and the American College of Medical Toxicology's Toxicology Investigators Consortium (ToxIC Registry). A case series of four patients from one medical toxicology service is also presented.During the 52-month study period, a total of 3192 vilazodone human exposures were reported to NPDS. Of these, 1734 (54

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