Helicobacter pylori eradication improves the prognosis of peptic ulcer disease (PUD), dyspepsia, and possibly gastric cancer. H pylori screening tests are accurate and eradication therapy is effective. H pylori population screening seems attractive. The aim of this study was to evaluate the long-term effect of H pylori population screening and eradication on dyspepsia prevalence and the incidence of PUD, and as secondary outcomes to assess the effect on health care consumption and quality of life.At baseline in 1998 to 1999, 20,011 individuals aged 40 to 65 years were randomized to H pylori screening and eradication or a control group with no screening. Both groups received a questionnaire on dyspepsia and quality of life. Register data were obtained for all randomized individuals.The baseline questionnaire response rate was 63

作者：Maria Bomme, H?gh；Jane M?ller, Hansen；Mette, Wildner-Christensen；Jesper, Hallas；Ove B, Schaffalitzky de Muckadell

来源：Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2017 年