Methadone versus Fentanyl in Patients with Radiation Induced Nociceptive Pain with Head and Neck Cancer, a randomized controlled non-inferiority trial.-临床诊疗知识库

Methadone versus Fentanyl in Patients with Radiation Induced Nociceptive Pain with Head and Neck Cancer, a randomized controlled non-inferiority trial.

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作者：

Johan, Haumann；Sander M J, van Kuijk；José W, Geurts；Frank J P, Hoebers；Bernd, Kremer；Elbert A, Joosten；Marieke H J, van den Beuken-van Everdingen

来源：

Pain practice : the official journal of World Institute of Pain 2017 年

标签：

Cancer Fentanyl Head and Neck Methadone Pain Radiotherapy

Pain is still a burden for many patients with cancer. A recent trial showed superiority of methadone over fentanyl in neuropathic pain, and we expect that this could increase the amount of patients treated with methadone.We performed a randomized controlled non-inferiority trial in patients with nociceptive pain. 82 strong-opioids naive patients with head-and-neck cancer with substantial pain (pain NRS≥4) due to radiation therapy were included. Forty-two patients were treated with methadone, and forty with fentanyl. Patients were evaluated at one, three, and five weeks. The primary outcomes were reduction in average pain and clinical success (50

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