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Although the natural history of urothelial carcinoma of the bladder (UCB) from radical cystectomy (RC) to disease recurrence (DR) has been investigated intensively, the course of patients who have experienced DR after RC for UCB remains poorly understood.To evaluate the prognostic value of the Bajorin criteria that consists of two risk factors: Karnofsky performance status (KPS) and the presence of visceral metastases (VMs) in patients with DR after RC for UCB. Furthermore, to identify additional factors associated with cancer-specific mortality (CSM) and thus build a multivariable model to predict survival after DR.We identified 967 patients with UCB who underwent RC at 17 centers between 1979 and 2012 and experienced DR. Of these, 372 patients had complete data we used for analysis.Univariable Cox regressions analysis was performed. We used a forward stepwise selection process for our final multivariable model.Within a median follow-up of 18 mo, 266 patients died of disease. Cancer-specific survival at 1 yr was 79

作者:Luis A, Kluth;Evanguelos, Xylinas;Malte, Rieken;Matthew, Kent;Masaomi, Ikeda;Kazumasa, Matsumoto;Masayuki, Hagiwara;Eiji, Kikuchi;Megan T, Bing;Amit, Gupta;Joseph M, Sewell;Badrinath R, Konety;Tilman, Todenh?fer;Christian, Schwentner;Alexandra, Masson-Lecomte;Dimitri, Vordos;Florian, Roghmann;Joachim, Noldus;Aria A, Razmaria;Norm D, Smith;Evi, Comploj;Armin, Pycha;Michael, Rink;Jack, Baniel;Roy, Mano;Giacomo, Novara;Atiqullah, Aziz;Hans-Martin, Fritsche;Antonin, Brisuda;Trinity, Bivalacqua;Paolo, Gontero;Stephen A, Boorjian;Andrew J, Vickers;Shahrokh F, Shariat

来源:European urology focus 2015 年 1卷 1期

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作者:
Luis A, Kluth;Evanguelos, Xylinas;Malte, Rieken;Matthew, Kent;Masaomi, Ikeda;Kazumasa, Matsumoto;Masayuki, Hagiwara;Eiji, Kikuchi;Megan T, Bing;Amit, Gupta;Joseph M, Sewell;Badrinath R, Konety;Tilman, Todenh?fer;Christian, Schwentner;Alexandra, Masson-Lecomte;Dimitri, Vordos;Florian, Roghmann;Joachim, Noldus;Aria A, Razmaria;Norm D, Smith;Evi, Comploj;Armin, Pycha;Michael, Rink;Jack, Baniel;Roy, Mano;Giacomo, Novara;Atiqullah, Aziz;Hans-Martin, Fritsche;Antonin, Brisuda;Trinity, Bivalacqua;Paolo, Gontero;Stephen A, Boorjian;Andrew J, Vickers;Shahrokh F, Shariat
来源:
European urology focus 2015 年 1卷 1期
标签:
Bladder cancer Disease recurrence Metastasis Model Prognosis Survival Transitional cell carcinoma Urothelial carcinoma of the bladder
Although the natural history of urothelial carcinoma of the bladder (UCB) from radical cystectomy (RC) to disease recurrence (DR) has been investigated intensively, the course of patients who have experienced DR after RC for UCB remains poorly understood.To evaluate the prognostic value of the Bajorin criteria that consists of two risk factors: Karnofsky performance status (KPS) and the presence of visceral metastases (VMs) in patients with DR after RC for UCB. Furthermore, to identify additional factors associated with cancer-specific mortality (CSM) and thus build a multivariable model to predict survival after DR.We identified 967 patients with UCB who underwent RC at 17 centers between 1979 and 2012 and experienced DR. Of these, 372 patients had complete data we used for analysis.Univariable Cox regressions analysis was performed. We used a forward stepwise selection process for our final multivariable model.Within a median follow-up of 18 mo, 266 patients died of disease. Cancer-specific survival at 1 yr was 79