To determine whether discontinuation of chronic antidepressant therapy is associated with a higher risk of antidepressant discontinuation syndrome (ADS) symptoms in patients admitted to the intensive care unit (ICU) when compared with those who were continued on therapy and to identify factors associated with increased risk of ADS in this population.Single-center retrospective observational cohort study.ICUs in a tertiary care hospital.One hundred-six adult patients, admitted to the ICU between September 2013 and August 2014, who had a length of stay ≥ 72 hours and who were receiving chronic selective serotonin (SSRI) or serotonin-norepinephrine reuptake inhibitors (SNRI) prior to admission.Patients were classified as continued or discontinued from therapy based on initiation of home SSRI/SNRI therapy within 48 hours of admission. The primary endpoint was incidence of ADS symptoms. Type of symptoms, receipt of symptom-related therapies, and length of stay were also assessed. Sequential logistic regression analysis was used to determine the impact of discontinuation while controlling for other risk factors. Therapy was discontinued in 38.7

作者：Taryn B, Bainum；David S, Fike；Diana, Mechelay；Krystal K, Haase

来源：Pharmacotherapy 2017 年