Anthracycline-induced cardiomyopathy is a serious side effect that ranges from mild left ventricular systolic impairment to congestive heart failure and cardiogenic shock. Currently, there is no evidence indicating the effective use of levosimendan in these cases.We aim to present a case of life-threatening doxorubicin-induced cardiomyopathy that was successfully managed with levosimendan.A 48-year-old female with formerly normal heart function, who had been treated with doxorubicin-based regimens for dedifferentiated chondrosarcoma, presented with cardiomyopathy with low left ventricular ejection fraction eight months after the last infusion. As treatment with ramipril, carvedilol, and furosemide followed by dopamine and noradrenaline was not sufficient, levosimendan was administered. Left ventricular ejection fraction increased from 15
作者:Nikolaos, Miaris;Stefanos, Zezas;Joseph, Sgouros;Dimitra-Christina, Zirou;Stefania, Gkoura;George, Stamoulis;Helen, Angelopoulou;George, Avgeropoulos;Epaminondas, Samantas
来源:Heart & lung : the journal of critical care 2017 年