Serum and tissue 25-OH vitamin D3 concentrations do not predict bone abnormalities and molecular markers of vitamin D metabolism in the hypovitaminosis D kyphotic pig model.-临床诊疗知识库

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The hypovitaminosis D kyphotic pig provides a model to study maternal vitamin D (D) carryover on gross and molecular characteristics of bone abnormalities in offspring. Excess maternal D is proposed to protect offspring under nutritional challenges from developing bone abnormalities. Relationships between D sufficiency parameters and bone abnormalities were characterised. Sows (n 37) were fed diets with 0 (-D), 8·125 (+D) or 43·750 (++D) µg D3/kg throughout gestation and lactation. At weaning (3 weeks) pigs were fed diets with 0 (-D) or 7·0 (+D) µg D3/kg, each with 75 and 95

作者：Laura A, Amundson；Laura L, Hernandez；Thomas D, Crenshaw

来源：The British journal of nutrition 2017 年 118卷 1期

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Serum and tissue 25-OH vitamin D3 concentrations do not predict bone abnormalities and molecular markers of vitamin D metabolism in the hypovitaminosis D kyphotic pig model.

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作者：

Laura A, Amundson；Laura L, Hernandez；Thomas D, Crenshaw

来源：

The British journal of nutrition 2017 年 118卷 1期

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OCN osteocalcin ++D 43·750 μg D3/kg +D 7·0 μg D3/kg +D 8·125 μg D3/kg D vitamin D LCa and HCa 0·52 and 1·05 LLQ limit of quantification PTH parathyroid hormone SRTC University of Wisconsin Swine Research and Teaching Center nursery diet LP and HP 0·57 and 0·72 nursery diet –D 0 μg D3/kg ?D 0 μg D3/kg 1α-Hydroxylase 24-Hydroxylase Calcium Kyphosis Maternal carryover Phosphorus Vitamin D sufficiency

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