The benefits and risks of long-term testosterone administration have been a topic of much scientific and regulatory interest in recent years.To assess long-term quality of life (QOL) and sexual function benefits of testosterone replacement therapy (TRT) prospectively in a diverse, multinational cohort of men with hypogonadism.A multinational patient registry was used to assess long-term changes associated with TRT in middle-age and older men with hypogonadism. Comprehensive evaluations were conducted at 6, 12, 24, and 36 months after enrollment into the registry.QOL and sexual function were evaluated by validated measures, including the Aging Males' Symptom (AMS) Scale and the International Index of Erectile Function (IIEF).A total of 999 previously untreated men with hypogonadism were enrolled at 25 European centers, 750 of whom received TRT at at least one visit during the period of observation. Patients on TRT reported rapid and sustained improvements in QOL, with fewer sexual, psychological, and somatic symptoms. Modest improvements in QOL and sexual function, including erectile function, also were noted in RHYME patients not on TRT, although treated patients showed consistently greater benefit over time in all symptom domains compared with untreated patients. AMS total scores for patients on TRT were 32.8 (95

作者：Raymond C, Rosen；Frederick, Wu；Hermann M, Behre；Hartmut, Porst；Eric J H, Meuleman；Mario, Maggi；Javier, Romero-Otero；Juan I, Martinez-Salamanca；Thomas Hugh, Jones；Frans M J, Debruyne；Karl-Heinz, Kurth；Geoff I, Hackett；Richard, Quinton；Peter, Stroberg；Yacov, Reisman；Edoardo S, Pescatori；Antonio, Morales；Lluis, Bassas；Natalio, Cruz；Glenn R, Cunningham；Olivia A, Wheaton

来源：The journal of sexual medicine 2017 年