Heart rate reduction with ivabradine improves left ventricular function and reverses multiple pathological maladaptations in dogs with chronic heart failure.-临床诊疗知识库

Heart rate reduction with ivabradine improves left ventricular function and reverses multiple pathological maladaptations in dogs with chronic heart failure.

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作者：

Hani N, Sabbah；Ramesh C, Gupta；Smita, Kohli；Mengjun, Wang；Kefei, Zhang；Sharad, Rastogi

来源：

ESC heart failure 2014 年 1卷 2期

标签：

Gene expression Heart failure Heart rate Inflammatory cytokines Ventricular remodelling

We tested the hypothesis that heart rate (HR) reduction with ivabradine (IVA) leads to reversal of structural, biochemical, and molecular maladaptations characteristic of the heart failure (HF) state. HR reduction with IVA has been shown to improve left ventricular (LV) systolic function and clinical outcome in patients with HF.Studies were performed in 16 HF dogs produced by intracoronary microembolizations [LV ejection fraction (EF) ~35

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