Autochthonous hepatitis E is increasingly recognized as zoonotic infection in western countries. Serologic assays have varying sensitivity and specificity.We implemented molecular testing to identify and characterize acute hepatitis E acquired in Switzerland.Ninety-three cases of mostly symptomatic acute hepatitis E acquired in Switzerland were documented by PCR between November 2011 and December 2016. Median HEV RNA was 7.5 x 104 IU/ml (range, 5.3 to 4.7 x 107 IU/ml). HEV genotyping was successful in 78 patients, revealing genotype 3 in 75 and genotype 4 in 3 patients. Phylogenetic analyses revealed a few limited geographial and temporal clusters. Of the 91 patients with available anti-HEV IgM serology, 4 were negative; three of these were also IgG-negative, likely as a result of immunosuppression, and one was IgG positive, a constellation compatible with HEV reinfection. Median age of the patients was 58 years (range, 20-80 years); 71 (76.3

作者：Montserrat, Fraga；Christopher, Doerig；Hervé, Moulin；Florian, Bihl；Felix, Brunner；Beat, Müllhaupt；Paolo, Ripellino；David, Semela；Felix, Stickel；Benedetta Terziroli, Beretta-Piccoli；Vincent, Aubert；Amalio, Telenti；Gilbert, Greub；Roland, Sahli；Darius, Moradpour

来源：Liver international : official journal of the International Association for the Study of the Liver 2017 年