The aim of this study was to identify determinants of submaximal exercise capacity as measured by 6 min walking distance in patients at risk for heart failure with preserved ejection fraction (HFpEF).A cross-sectional analysis from the prospective cohort programme Prevalence and Clinical Course of Diastolic Dysfunction and Heart Failure (DIAST-CHF) that included a total of 1937 patients (age, 50-85 years) with >1 risk factor (hypertension, atherosclerotic disease, diabetes mellitus, and obstructive sleep apnoea) was carried out. Besides comprehensive clinical phenotyping, standardized 6 min walk test and state-of-the-art echocardiography were performed, and blood samples for biomarker assessment were obtained. Patients with an ejection fraction <50

作者：Raoul, Stahrenberg；André, Duvinage；Meinhard, Mende；G?tz, Gelbrich；Wiebke, Auf der Heide；Hans-Dirk, Düngen；Lutz, Binder；Kathleen, Nolte；Christoph, Herrmann-Lingen；Gerd, Hasenfu?；Burkert, Pieske；Rolf, Wachter；Frank, Edelmann

来源：ESC heart failure 2015 年 2卷 2期