With the aging of society and the development of medically diagnostic techniques,the incidence and diagnosis rate of Alzheimer's disease (AD) have been increasing.However,there is no breakthrough in the treatment of AD at present.Thus,it is necessary to explore the optimal management for AD patients under the current condition.AD is characterized by multi-target mechanisms of pathogenesis and complexity of clinical symptoms,which requires more comprehensive treatment and management.Here,we elaborate of A2G plus (one or more of A to G and other plus measures) comprehensive management model for AD patients.This model is built upon 4 international authoritative guidelines,multi-target mechanisms of disease,existing therapeutic drugs and methods,and long-term clinical experiences and patient' s individual condition,and provides a new model of comprehensive treatment and management for AD patients.

作者：彭丹涛

来源：第三军医大学学报 2016 年 38卷 15期