Background and Objective: Concurrent chemoradiation therapy (CCRT) is the standard treatment for patients with locally advanced nasopharyngeal carcinoma (NPC). The effect of neoadjuvant chemotherapy followed by CCRT has not been determined. Therefore, we conducted 2 phase II studies to evaluate the efficacy and safety of neoadjuvant chemotherapy with a regimen of docetaxel, cisplatin, and 5-fluorouracil (5-Fu) (TPF) followed by radiotherapy and concurrent cisplatin in patients with stage-Ill and -IV (A - B) NPC. This article is the preliminary report on treatment-related toxicities and response. Methods: Graded according to the 2002 American Joint Committee on Cancer (AJCC) staging criteria, only patients with stage-Ill or -IV(A - B) poorly differentiated or undifferentiated NPC (World Health Organization type ll/lll) were included. We planned to recruit 52 patients with stage-Ill disease and 64 patients with stage-IV(A - B) disease. All patients received neoadjuvant chemotherapy with TPF (docetaxel 75 mg/m

作者：孔琳；张有望；胡超苏；Ye Guo

来源：癌症 2010 年 29卷 5期