Background and Objective: In patients with hepatocellular carcinoma (HCC) receiving potentially curative minimally invasive therapy, autologous cytokine-induced killer (CIK) cells were used to reduce recurrence. In this study we observed the changes in serum alpha-fetoprotein (AFP) after the treatment with CIK cells to explore if AFP could serve as a marker for predicting immunotherapeutic clinical outcome. Methods: A total of 122 patients with HCC and elevated AFP (> 25 ng/mL) 收稿日期: a curative treatment of transcatheter arterial chemoembolization (TACE) plus radiofrequency ablation (RFA) at the Sun Yat-sen University Cancer Center. Of these patients, 83 patients without residual tumor or extrahepatic metastasis and with AFP level less than 1.5 times the normal range (AFP < 37.5 ng/mL) were randomly assigned to the study group (n = 42) and the control group (n = 41). In the study group, CIK cells were transfused intravenously or via common hepatic arteries every week for at least 4 times, and the T-lymp

作者：潘长穿；黄子林；李旺；Ming Zhao；Qi-Ming Zhou；Jian-Chuan Xia；Pei-Hong Wu

来源：癌症 2010 年 29卷 6期