糖尿病性黄斑水肿 ( diabetic macular edema, DME) 是导致糖尿病患者中心视力受损的重要原因之一, DME发病机制复杂, 主要是由于血 -视网膜屏障破坏, 血管通透性增加所致.血管内皮生长因子 ( vascular endothelial growth factor, VEGF) 及各种炎症因子共同参与了 DME 的病理发展过程.激光光凝和抗VEGF治疗是目前治疗DME的有效方法, 玻璃体腔内注射糖皮质激素也被广泛应用.本文就DME的发病机制及治疗进展做一综述. [Abstract] Diabetic macular edema (DME) is an important cause of visual impairment in diabetic patients. DME is mainly caused by the disruption of blood-retinal barrier and the leakage of retinal vessels. Vascular endothelial growth factors (VEGF) and other inflammatory factors are involved in the pathogenesis of DME. Laser photocoagulation and anti -VEGF therapy are effective methods in the treatment of DME. Intravitreal injection of glucocorticoids is also widely used. This article reviews the pathogenesis and treatment of DME.

作者：郭永兰；赵亮亮；聂黎黎；赵梅生

来源：国际老年医学杂志 2019 年 40卷 2期