Objective:To explore the differences of obese Sprague-Dawley (SD)rats model induced by lard oil high-fat (HF)diet or purified HF diet.Methods:SD weanling rats were randomly divided into three groups:D1 group,where rats were fed by lard oil HF diet;D2 group,where rats were fed by purified HF diet;C group,where rats were fed on chow.After 12 weeks,diet-induced obesity rats (top 33％ based on weight)were selected for further study,and the rest rats from group D1 and D2 were excluded.The food intake and weight were weighted daily and weekly,respectively.The subcutaneous,visceral and total fat contents of rats was measured by 256-row CT scan and the Lee index was calculated accordingly.The kidney,liver,testis,spleen and heart were weighted respectively.Serum leptin and insulin levels were quantified.The pathology in liver and adipose tissues were analyzed by HE staining.Oral glucose tolerance test (OGTT)was used to compare the glucose tolerance ability.Serum total cholesterol (T-CHO),high density lipoprotein (HD

作者：Shanlei Zhang；Wenqing Mo；Xi Rong；Fang Wei；Hong Liu；Fuling Huang

来源：广西医科大学学报 2018 年 35卷 1期