Objective:To study the leptin receptor Gln223Arg locus polymorphism in patients with asthma and its correlation with the disease progression.Methods: The patients who were diagnosed with bronchial asthma in our hospital between July 2014 and April 2017 were selected as the asthma group for the study, and the healthy volunteers who received physical examination in our hospital during the same period were selected as the control group. The leptin receptor gene Gln223Arg locus polymorphism was determined, and the contents of inflammatory mediators and airway remodeling indexes in serum as well as the contents of immune cells in peripheral blood were determined.Results: Eotaxin, Galectin-3, YKL-40, SAA, IL-33, ADAM33, NE and MMP9 contents in serum as well as Th17, Th9 and Tfh contents in peripheral blood of asthma group of patients with AA+AG genotype and GG genotype were significantly higher than those of control group whereas TIMP1 and TIMP2 contents in serum as well as Treg contents in peripheral blood were

来源：海南医学院学报 2018 年 24卷 10期