大肠癌 中医药治疗 化疗 消化道反应 骨髓抑制 免疫抑制 肝肾损害 神经毒性 增效减毒 耐药性 colorectal cancer traditional Chinese medicine treatment chemotherapy gastrointestinal reaction myelosuppression immu- nosuppression damage of liver and kidney neurotoxicity effect-enhancing and toxicity-reducing tolerance