Ganoderma lucidum(Leyss.Ex fr.)Karst.(Lingzhi) is a medicinal fungus with a long history in China as a valuable tonic remedy.Modern Pharmacological and clinical investigation demonstrated that Lingzhi had anti-tumor activities.Recently the antitumor effects of extract of Ganoderma lucidum(GLE) and Ganoderma polysaccharides B(GL-B) and its mechanism were investigated.The results demonstrated that GLE and GL-B significantly inhibited growth of implanted sarcoma 180 in vivo.GL-B also promoted anti-tumor activity induced by cyclophosphamide in mice in vivo.GLE and GL-B directly adding to tumor cells-cultured medium neither suppressed sarcoma 180 and HL-60 proliferation nor induced apoptosis of both tumor cells in vitro.However the serum from GLE and GL-B treated mice can suppress S-180 and HL-60 cells proliferation and induced its apoptosis in vitro.Furthermore splenocytes conditioned medium with GL-B (GL-B-S-CM) and peritoneal macrophages conditional medium with GL-B (GL-B-PM-CM) also significantly i
作者:林志彬
来源:基础医学与临床 2000 年 20卷 5期