Objective:To investigate the correlation between 17-beta-hydroxysteroid dehydrogenase type1 ( 17β-HSD-1 ) gene polymorphisms and risk of endometrial adenocarcinoma.Methods:Forty-one patients with endometrial adenocarcinoma were selected as experimental group and twenty-seven healthy women were selected as control group.The three common single nucleotide polymorphism of 17β-HSD-1 gene at sites+1004,+1322 and +1954 were detected by allele-specific PCR (ASA-PCR).The allele frequencies were analyzed by SPSS13.0 software between endometrial cancer cases and controls.Results:We observed no significant difference in various frequency distribution between experimental group and control group.P1004 =0.994,P1322 =0.974,and P1954 =0.981.Conclusion:We found that three common SNPs with the 17β-HSD-1 gene were not associated with endometrial adenocarcinoma.We suggest that more research for 17β-HSD needs to explore.

来源：现代妇产科进展 2011 年 20卷 8期