Objective To study the effect of medroxyprogesterone on body weight loss,myelosuppression, anorexia and quality of life (QOL) in patients with advanced neoplasm.Method 37 patients in group A received 200 mg domestic medroxyprogesterone capsule,three times a day for 4 consecutive weeks.37 patients in group B received 500 mg tablet of import medroxyprogesterone,once a day for 4 consecutive weeks. Result Therapeutic effect of domestic and import medroxyprogesterone was similar of group A and B in terms of anoxia,body weight loss,QOL(P >0.05).Side effects included abnormal liver function,edema,and moon shaped face.Conclusion Medroxyprogesterone belongs to supportive therapy for patients with advanced tumor,which can improve QOL.Therapeutic effect of middle dose medroxyprogesterone is satisfying.

作者：江澜；江咏梅；奚昊

来源：中国临床康复 2002 年 6卷 10期