AIM:To study the effect of cerebral ischemia-reperfusion (CI/RP) injury onthe function and cycle of T cells in rat. METHODS: Using animal model ofbrain ischemia-reperfusion injury, H-TdR incorporation and flow cytometer todetect the change of T cell function and cell cycle. RESULTS: After CI/RP, the proliferation ability, clone formation rate and IL-2 production abilityof T cells of experimental group were apparently lower than those of controlgroup (P＜0.01), and it more apparent with prolonged ischemia time;with CI/RP the recovery of 3-hour group was more rapid than that of 6-hourgroup; after CI/RP injury, the proliferation cycle of T cells in each groupschanged, the cells in G0/G1 stage were more than those of control group (P＜0.01); while the cells in S + G2 + M stages were few than those of controlgroup (P＜0.01); when CI/RP, amount of cells in Go/G1 stage decreasegradually and that of cells in S +G2 +M stages increase gradual-ly. CONCLUSION: after CI/RP, the function of rat spleen T cells decreaseand

作者：陈爱娟；卓安山；国瑞琪；陈远芳；攸连秀

来源：中国临床康复 2003 年 7卷 3期