Objective Hypoglycemic Ziyabiti Tablets (HZT) is a traditional multicomponent treatment for diabetes in Xinjiang Uyghur Traditional Medicine.The present study aimed to investigate the effect of HZT in diabetic rats and its activity in cultured liver cells to investigate the relative mechanisms.Methods 10 days high-fat diet fed rats were intraperitoneally injected with alloxan (ALX) at next two subsequent days to induce diabetes mellitus (DM).Then were divided into 5 groups:saline,positive DM control and DM groups treated with different doses of HZT.Fasting blood glucose (FBG),total cholesterol (TC),total triglycerides (TG),high-density lipoprotein (HDL-C),fasting insulin (FI),insulin secretion (IS) and insulin sensitivity index (ISI) were measured.The IC50 of HZT in L-02 cells was determined by MTT assay,in intact and in paracetamol-induced liver injury (Par),on lactate dehydrogenase (LDH) activity and on glucose consumption.Results HZT decreased FBG and TC (P ＜0.05),increased IS (P ＜0.05) and at 440 mg

作者：LI Guirong；FAN Yong；Moore N；WANG Xiaofeng；SHANG Jing；LIU Jianzhong；WANG Ye；LI Linlin

来源：新疆医科大学学报 2017 年 40卷 12期