The incidence of spinal cord injury is very high, which often brings disastrous consequences to the patients and their families. And there is no ideal treatment. In recent years, with the in-depth study on molecular biology and genetic engineering technology, cell transplantation as the biotherapy strategy and treatment for spinal cord injury has been developed. Schwann cells have become the focus of research because of their obvious advantages for nerve repair. Schwann cells are easy to obtain and culture, and can reduce the immune rejection after autologous transplantation, which lead to no ethical restrictions. Schwann cells transplanted into the damaged spinal cord can swallow necrotic tissues, reduce tissue defects and secrete neurotrophic factors, adhesion molecules and extracellular matrices, which can promote the growth of axons and myelins, and further improve the sensory and motor function. However, due to the bad local micro environment, the promotion of axonal growth and remyelination is limited

作者：钱隆；张小雷；黄亮节；刘彦；唐家广

来源：中国骨与关节杂志 2017 年 6卷 5期