BACKGROUND:Recent studies have paid much attention to the newly found neuregulin-1,which might be closely linked to the molecular genetics of schizophrenia. OBJECTIVE:To investigate the association of neuregulin-related genes with schizophrenia,and to summarize the advancements in this current research. RETRIEVAL STRATEGY:Using the terms "neuregulins,gene,schizophrenia",we retrieved articles published from January 2000 to June 2007 from http://www.ncbi.nlm.gov,http://www.elsevier.lib.tsinghua.edu.cn,and http://www.cjfd.cnki.net to identify studies addressing the association of neuregulin-related genes to schizophrenia.At the same time,we searched more than 10 medical journals by hand.The languages were limited to English and Chinese.Forty-two manuscripts were obtained and were firstly screened.Inclusion criteria:studies on neuregulins,schizophrenia,neuregulin-1, and the pathogenesis of schizophrenia,including randomized,blinded,and other original studies.Exclusion criteria:studies not related to schizophren

来源：中国神经再生研究（英文版） 2008 年 3卷 2期