Background::Degree of mucosal recovery is an important indicator for evaluating the therapeutic effects of drugs in treatment of inflammatory bowel disease (IBD). Increasing evidences has proved that tight junction (TJ) barrier dysfunction is one of the pathological mechanisms of IBD. The aim of this study was to observe whether enhancement of TJ can decrease colitis recurrence.Methods::Eighty C57BL/6 mice were randomly divided into four groups including normal group, colitis group, sulfasalazine (SASP) treated group, and traditional Chinese drug salvianolic acid B (Sal B) treated group. Colitis was established in mice by free drinking water containing dextran sulfate sodium, after treatments by SASP and Sal B, recombinant human interleukin-1β (IL-1β) was injected intraperitoneally to induce colitis recurrence.Results::Compared with sham control, cell apoptosis in colitis group was increased from 100.85 ± 3.46

作者：Feng Pan-Pan；Fang Xue-Sheng；Zhao Si-Hui；Fu Jun-Yan；Zhang Hui-Ting；Yi Yan-Lin；Li Chang-Yi；Jiang Chun-Ling；Chen Da-Peng

来源：中华医学杂志英文版 2020 年 133卷 12期